RI
Dr. Radha IyengarBreast Surgery

Molecular subtypes of breast cancer

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There are four subtypes of invasive breast cancer: luminal A, luminal B, her2 enriched, and triple negative.
Luminal A cancers are hormone receptor positive and her2 negative. This means they can be estrogen and/or progesterone receptor positive but the her2 receptor is negative. 
Luminal A cancers tend to be slow growing and less aggressive and typically are very responsive to anti-hormonal therapy. 
Luminal B cancers are also hormone receptor positive and her two negative. They can be estrogen and/or progesterone receptor positive but the her2 receptor is negative. 
Luminal B cancers tend to be more aggressive than luminal a cancers and are associated with poorer survival than luminal A cancers. 
Her2 enriched cancers are any cancers that are her2 receptor positive, regardless of the hormone receptor status. 
These cancers tend to grow and spread more aggressively and are associated with poorer short term prognosis. 
Triple negative cancers do not have any of the receptors. This means the estrogen, progesterone, and her two receptors are negative. 
These cancers are very aggressive and are associated with the poorest short term prognosis.